Marketed and experimental medicines for the
treatment of Acne, Eczema and Psoriasis

Company	Product name /number	Product type	Target Disease	Phase of development					Status and comment (October 2000)
				PC	I	II	III	L
Abbott	Adalimumab (D2E7)	Human anti-TNFa MAb	Psoriasis						On trial for chronic plaque psoriasis and psoriatic arthritis. Licensed from UK’s Cambridge Antibody Technology plc (CAT)
Abgenix Inc.	ABX-IL8	Human anti-IL8 MAb	Psoriasis
Aeterna	AE-941	Anti-angiogenic	Psoriasis
Allergan	Tazarotene	Topical retinoid (vitamin A derivative)	Psoriasis & Acne						Licence for an oral form to be filed in the USA in 2003. Trials in nodulocystic acne ongoin
Alexion Pharmaceuticals	Eculizumab	Humanised anti-complement C5 MAb	Psoriasis
Angiotech Pharmaceuticals Inc	Micellar paclitaxel	Anti-angiogenic	Psoriasis
Astralis Ltd	Psoraxine	Natural product – type unknown	Psoriasis
BioCryst	BCX-1777	PNP inhibitor	Psoriasis & Eczema						Blocks T-cell division
Biogen-Idec	Alefacept	Anti-T-cell fusion protein	Psoriasis						Licensed in US only with IDEC
Boehringer-Ingelheim	BIBR-796	P38 kinase inhibitor	Psoriasis
Crookes	Tacalcitol	Vitamin D derivative	Psoriasis
Dermal	Benzalkonium chloride	Antibacterial	Eczema						Ingredient in antibacterial emollients
	Dithranol	Modified anthracene anti-inflammatory	Psoriasis & Acne						Also known as anthralin
DermaPharm	Salicylic acid	Salicylate	Acne
Eisai	HuMax-CD4	Human anti-CD4 MAb	Psoriasis						Licensed for Europe from Genmab
Fujisawa	Tacrolimus	Immunomodulator	Eczema						For moderate to severe disease unresponsive to other treatments
Galderma	Adapalene	Retinoid-like	Acne						First topical retinoid for acne
	Calcitriol	Vitamin D derivative	Psoriasis						(Launched)
Genmab	HuMax-IL15	Human anti-IL-15 MAb	Acne						Co-developed with Amgen
	HuMax-CD4	Human anti-CD4 MAb	Psoriasis
Hoffmann-La Roche	Acitretin	Retinoid (Vitamin A derivative)	Psoriasis						Hospital use only for severe forms of psoriasis
	Isotretinoin	Retinoid (Vitamin A derivative)	Acne						For severe forms of acne or when unresponsive to antibiotics
	Mycophenolate mofetil	Immunosuppressive	Eczema/ Psoriasis						Unlicensed use only in severe eczema and psoriasis
ISIS Pharmaceuticals	ISIS 104838	Antisense inhibitor of TNFa	Psoriasis						Oral formulation also in development
Isotechnika	ISA 247	Immunosuppressive related to cyclosporin	Psoriasis						Development globally with Roche
Janssen-Cilag	Tretinoin	Retinoid	Acne						(Also available from Crookes and Strakan)
Leo Pharma	Calcipotriol	Vitamin D derivative	Psoriasis						Cream and scalp solution available for plaque psoriasis
	Calcipotriol + betamethasone	Vitamin A + steroid	Psoriasis						Combination better than either component alone in stable plaque psoriasis
	Fusidic acid	Antibiotic	Eczema						For infected eczema lesions
	Fusidic acid + betamethasone	Antibiotic + steriod	Eczema						For infected eczema lesions
Ligand	ONTAK	Fusion protein	Psoriasis
	Bexarotene	Vitamin A derivative	Psoriasis
MedImmune Inc	Siplizumab	Humanised MAb CD2 receptor agonist	Psoriasis						On hold
Novartis	Pimecrolimus	Anti-inflammatory	Eczema						Cream for mild to moderate condition
	Crotamiton	Anti-pruritic	Eczema						For control of itching associated with eczema
	Cyclosporin	immuno-suppressive	Psoriasis						For severe disease unresponsive to other treatments
PDL	Fontolizumab	Humanised anti-interferon-g MAb	Psoriasis
Pfizer/Pharmacia	Azithromicin	Macrolide antibiotic	Acne						In late-stage assessment in acne
	Clindamycin	Antibacterial	Acne
	Methotrexate	Immunosuppressant	Psoriasis						For severe disease unresponsive to other treatments
	Spironolactone	Thiazide diuretic	Acna						Available for heart failure. Low dose use in acne under assessment
Schering Health Care	Azelaic acid	Antibacterial	Acne						For refractory acne in women
	Cyproterone acetate + ethinylestradiol	Antibacterial Hormonal preparation	Acne
Schering- Plough	Infliximab	Anti-TNFa monoclonal antibody	Psoriasis						Approved by the FDA in the USA
Schwarz Pharma	Benzamycin	Anti-bacterial	Acne
Serono	Efalizumab	Humanised anti-CD11a MAb	Psoriasis						Approved in USA in Sept. 2003 to Xoma and Genentech. UK launch (Serono) expected 2004
SR Pharma	SRP299	Vaccine	Eczema						Co-development with Genesis Research, New Zealand
	AVACTM	Vaccine	Eczema						Co-development with Genesis Research, New Zealand
Stiefel Laboratories	Isotretinoin topical	Retinoid (Vitamin A derivative)	Acne
	Isotretinoin/ erythromycin topical	Retinoid -antibiotic combination	Acne
Strakan	Clindamycin	Anti-bacterial	Acne
Takeda	TAK-427	Immunosuppressive	Eczema						Active in experimental models of eczema
Wyeth	Etanercept	Soluble-TNFa receptor Psoriasis fusion protein	Psoriasis						Launched for psoriatic arthritis. License application for psoriasis in USA filed July 2003
	Sirolimus	Immunosuppressive	Psoriasis & Eczema						Used in tissue transplantation
Yamanouchi	Erythromycin/ zinc combination	Antibacterial	Acne
	Chlorquinaldol/ hydrocortisone 17-butyrate combination	Antibacterial & antifungal + steroid	Eczema
PC, I, II, III = Preclinical and Phase I, II and III clinical trials; PR = Pre-registration; L = Licensed/Authorised; IL = Interleukin; MAb = Monoclonal antibody; TNFa = Tumour Necrosis Factor-alpha

< Previous Page | Contents | Next Page >