 |
| Company |
Product name
/number |
Product
type |
Phase of development |
Status and
comment
(October 1998) |
| PC |
I |
II |
III |
L |
|
| Abbott Laboratories |
Divalroex sodium |
Slow release form of valproate |
 |
|
|
|
|
USA only |
|
| Allelix Biopharmaceuticals |
ALX-0646 |
Novel type of triptan
serotonin (5HT1) antagonist |
|
 |
 |
|
|
Phase 1 trails conducted
in the UK |
|
| Aliance |
Ergotamine |
Ergot alkaloid |
|
|
|
 |
 |
|
| Methysergide |
Serotonin (5HT1) antagonist |
|
|
|
|
|
|
|
| AstraZeneca |
Metoprolol |
Heart-selective B-blocker |
|
|
|
|
|
|
| Propranolol |
Non-heart-selective B-blocker |
|
|
|
|
|
|
| Zolmitriptan |
Serotonin (5HT1) agonist |
|
|
|
|
|
|
|
| Aventis |
Vigabatrine |
GABA amino-transferase
inhibitor |
|
|
|
|
|
Available for epilepsy.
Some clinical reports of activity in migrine |
|
| Boehringer Ingelheim |
Clonidine |
Central x-agtagonist |
|
|
|
|
|
|
| BIBN 4096bs |
CRGP antagonist |
|
|
|
|
|
For the treatment of acute
migraine |
|
| CAMR (Centre for Applied
Microbiology & reasearch) |
NC-164 |
Derivative of botulinum |
|
|
|
|
|
Being studied for chronic
pain |
|
| CoCenesys |
Ganaxolone |
Brain-active steroid |
|
|
|
|
|
Acts on inflammation by
peptides acting on brain blood vessels |
|
| Elan Pharma |
Lysine acetylsalicylate |
Analgesic + prokinetic
anti-emetic |
|
|
|
|
|
Available in the UK from
April 2000 |
|
| Glaxo Wellcome |
Sumatriptan |
Serotonin (5HT1) agonist |
|
|
|
|
|
|
| Naratriptan |
Serotonin (5HT1) agonist |
|
|
|
|
|
|
| GV196771 |
Glycine antagonist |
|
|
|
|
|
In development for migraine
prevention |
|
| Leo |
Timolol |
Beta-blocker |
|
|
|
|
|
|
|
| Lundbeck |
Almotriptan |
Serotonin |
|
|
|
|
|
|
|
| Manx Pharma |
Isometheptene + paracetamol |
Vasoconstrictor + analgesic |
|
|
|
|
|
|
|
| Merck Sharp & Dolhme |
Cyproheptadine |
Antihistamine and 5-HT
antagonist |
|
|
|
|
|
For migraine prvention |
| Rizatriptan |
Serotonin (5HT1) agonist |
|
|
|
|
|
|
| Timotol |
Beta-blocker |
|
|
|
|
|
|
|
| Mylan Pharmaceuticals |
Dotarizine |
Calcium channel blocker |
|
|
|
|
|
Phase 2 in the USA |
|
| Novartis |
Metroprolol |
Heart-selective B-blocker |
|
|
|
|
|
|
| Dihydroergotamine |
Ergot alkaloid |
|
|
|
|
|
Specially formulated as
nasal spray |
| Metysergide |
Ergot alkaloid |
|
|
|
|
|
|
| Pizotifen |
Serotonin (5HT1) agonist |
|
|
|
|
|
|
|
| Pfizer |
Buclizine + paracetamol |
Anti-emetic + analagesic |
|
|
|
|
|
|
| Eletriptan |
Serotonin (5HT1) |
|
|
|
|
|
|
|
| Pharmacia & Upjohn |
PNU-142633 |
Serotonin (5HT1) agonist |
|
|
|
|
|
|
|
| Reckitt & Colman |
Prochlorperazine |
Anti-emetic |
|
|
|
|
|
|
|
| Sanofi-Synthelabo |
Nadolol |
Non-heart-selective B-blocker |
|
|
|
|
|
|
| Ergotamine |
Ergot alkaloid |
|
|
|
|
|
|
| Metaclopramide + paracetamol |
Anti-emetic + analgesic |
|
|
|
|
|
|
|
| Servier |
Domperidone + paracetamol |
Anti-emetic + analgesic |
|
|
|
|
|
|
|
| SmithKline Beechham |
SR 220453 |
Serotonin (5HT1) agonist |
|
|
|
|
|
|
|
| Vanguard Medica |
Frovatriptan |
Serotonin (5HT1) partial
agonist |
|
|
|
|
|
|
|
